The researchers aimed to provide an up-to-date evidence summary about the comparative benefits and harms of drugs for adults with overweight or obesity.
The study involved randomised controlled trials of 12 weeks’ duration or longer comparing one or more drugs with lifestyle modification, placebo or another drug.
Researchers concluded that obesity drugs produce variable weight loss at one year, with larger benefits generally accompanied by greater harms and discontinuation. It found that agents do not improve quality of life meaningfully and few show cardiovascular benefits.
The researchers came to the conclusion that decisions in clinical practice should consider trade-offs between benefits and harms within the context of shared decision-making.
About the Author: Erin Dearlove
The researchers aimed to provide an up-to-date evidence summary about the comparative benefits and harms of drugs for adults with overweight or obesity.
The study involved randomised controlled trials of 12 weeks’ duration or longer comparing one or more drugs with lifestyle modification, placebo or another drug.
Researchers concluded that obesity drugs produce variable weight loss at one year, with larger benefits generally accompanied by greater harms and discontinuation. It found that agents do not improve quality of life meaningfully and few show cardiovascular benefits.
The researchers came to the conclusion that decisions in clinical practice should consider trade-offs between benefits and harms within the context of shared decision-making.
About the Author: Erin Dearlove
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